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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: This includes the discussion about underlying mechanism such as immunogenic cell death, which initiates

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: agent, inhibited the proliferation and viabilities of lung cancer cells and induced ferroptosis-like celldeath in vitro.

Keywords： orlistat     ferroptosis     FAF2     lung cancer    

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Using mRNA to investigate the effect of low-pressure ultraviolet disinfection on the viability of

Chao Yang, Wenjun Sun, Xiuwei Ao

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 2, doi: 10.1007/s11783-019-1111-x

Abstract:

Programmed cell death was not found to be more

Keywords： UV disinfection     Viability     mRNA     SOS response     Programmed cell death    

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Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 760-765 doi: 10.1007/s11684-021-0899-5

Abstract: outcomes of patients awaiting lung transplantation (LTx) after the implementation of donation after brain death

Keywords： lung transplantation     donation after brain death     waitlist    

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The influence of brain death on donor liver and the potential mechanisms of protective intervention

Shui-Jun ZHANG, Tao WANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 8-14 doi: 10.1007/s11684-011-0109-y

Abstract: Studies conducted in the past 10 years have shown that brain death is associated with effects on theHowever, whether the decrease in the viability of donor organs is caused by brain death or by the eventsbefore and after brain death remains uncertain.purpose of this review is to introduce the advances and controversies regarding the influence of brain death

Keywords： brain death     donor liver    

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Experimental study on the establishment and maintenance of brain death model with pigs

ZHANG Shuijun, SHI Jihua, ZHAI Wenlong, SONG Yan, CHEN Shi

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 161-166 doi: 10.1007/s11684-007-0030-6

Abstract: This study sought to explore methods of establishing a stable brain death (BD) model using Bama minibrain-dead state for a comparatively long period to provide a model for investigating changes in brain deathIn the BD group, 10 pigs met the requirements for brain death and 1 died of cardiopulmonary complicationsBrain death was maintained for more than 48 hours with artificial life support.

Keywords： BD     control     Hemodynamic     cardiopulmonary     modified    

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Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 338-342 doi: 10.1007/s11684-007-0065-8

Abstract: manifestations and pathological changes, were mainly seen in young men and is one of the main causes of sudden death

Keywords： sarcoplasmic coagulation     acquired     ventricular myocardium     sino-atrial     autopsied    

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Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 70-74 doi: 10.1007/s11684-008-0013-2

Abstract: To investigate the relationship between protein aggregation and delayed neuronal death, we adopted ratThe results showed delayed neuronal death took place at 72 h after ischemia-reperfusion, protein aggregatesWe conclude that protein aggregation is one of the important factors leading to delayed neuronal death
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Assessing the premature death due to ambient particulate matter in China’s urban areas from 2004 to 2013

Guoxia MA, Jinnan WANG, Fang YU, Xiaomin GUO, Yanshen ZHANG, Chao LI

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 5, doi: 10.1007/s11783-016-0849-7

Abstract: The number of annual premature deaths attributable to China’s air pollution ranged from 350000 to 520000 from 2004 to 2013, while the figure in 2013 reached 9.9% of total deaths in China. In 2004, the life expectancy potential years of life lost was 69.6 and 1.85 years respectively in contrast to 74.4 and 0.67 years respectively in 2013. The number of PYLL attributable to air pollution in the northern regions is found to be larger than that of the southern regions. The Environmental Burden of Disease (EBD) approach for outdoor air pollution has been used to calculate premature deaths and average potential years of life lost attributable to air pollution in China over the past 10 years with differences between the North and the South of the country being analyzed. The results indicate that: (1) Between 2004 and 2013, annual premature deaths attributable to outdoor air pollution in China ranged from 350000 to 520000. In 2013, deaths resulting from air pollution in China represented 9.9% of the country’s total deaths. (2) In 2004, the average life expectancy of the Chinese population and the number of potential years of life lost (PYLL) attributable to air pollution was 69.6 and 1.85 years respectively as compared to 74.4 and 0.67 years respectively in 2013. (3) The number of the PYLL attributable to air pollution in the northern regions of China is found to be larger than that of the southern regions. The PYLL figures of the northern and southern regions in 2004 were 2.3 and 1.8 years, respectively, with a difference of 0.5 years, as compared to 1.4 and 0.7 years respectively with a difference of 0.7 years in 2013.

Keywords： Air pollution     Public health     Premature deaths     Health assessment    

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The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 333-344 doi: 10.1007/s11684-013-0275-1

Abstract:

This study reports the first death caused by a novel avian influenza A (H7N9) virus in Zhejiang Provincelate diagnosis, and untimely antiviral treatment are possible high-risk factors for infections and death

Keywords： avian influenza A (H7N9) virus     epidemiology     contacts     person-to-person transmission    

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Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light one?

Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 420-426 doi: 10.1007/s11684-019-0688-6

Abstract: This article presents a synopsis of the current data on the mechanisms of blood—brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia—reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising.

Keywords： stroke     blood–brain barrier     autoimmunity     innate immunity     inflammation     cell death    

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Pseudomonas Cyclic Lipopeptide Medpeptin: Biosynthesis and Modulation of Plant Immunity Article

Yi-Lin Gu, Jun-Zhou Li, Yan Li, Shen Cong, Jing Wang, Yi-Nan Ma, Hai-Lei Wei

Engineering 2023, Volume 28, Issue 9,   Pages 153-165 doi: 10.1016/j.eng.2023.05.016

Abstract: research indicates that medpeptin does not exhibit antimicrobial activity; instead, it induces plant celldeath immunity and confers resistance to bacterial infection.Silencing of a cell-wall leucine-rich repeat extensin protein (NbLRX3) or a receptor-like protein kinase(NbRLK25)—but not BAK1 or SGT1—compromises medpeptin-triggered cell death and resistance

Keywords： Pseudomonas     Cyclic lipopeptide     Cell death     Leucine-rich repeat extension (LRX)     Medpeptin     Receptor-like    

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 90-98 doi: 10.1007/s11705-015-1550-2

Abstract: The well-designed microscale intermediary is also ideal for the study of cell biology.Particularly, microfluidic chip is helpful for better understanding cell-cell interactions.

Keywords： microfluidic chip     co-culture     cell-cell interactions     review    

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine   Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cellMNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cellThese MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting

Keywords： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing    

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Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 451-462 doi: 10.1007/s11684-018-0651-y

Abstract: Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential

Keywords： deubiquitinase     ubiquitination     T cell activation     T cell differentiation     T cell tolerance    

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Title Author Date Type Operation

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Orlistat induces ferroptosis-like cell death of lung cancer cells

Journal Article

Using mRNA to investigate the effect of low-pressure ultraviolet disinfection on the viability of

Chao Yang, Wenjun Sun, Xiuwei Ao

Journal Article

Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death

Journal Article

The influence of brain death on donor liver and the potential mechanisms of protective intervention

Shui-Jun ZHANG, Tao WANG

Journal Article

Experimental study on the establishment and maintenance of brain death model with pigs

ZHANG Shuijun, SHI Jihua, ZHAI Wenlong, SONG Yan, CHEN Shi

Journal Article

Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Journal Article

Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei

Journal Article

Assessing the premature death due to ambient particulate matter in China’s urban areas from 2004 to 2013

Guoxia MA, Jinnan WANG, Fang YU, Xiaomin GUO, Yanshen ZHANG, Chao LI

Journal Article

The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Journal Article

Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light one?

Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov

Journal Article

Pseudomonas Cyclic Lipopeptide Medpeptin: Biosynthesis and Modulation of Plant Immunity

Yi-Lin Gu, Jun-Zhou Li, Yan Li, Shen Cong, Jing Wang, Yi-Nan Ma, Hai-Lei Wei

Journal Article

Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Journal Article

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Journal Article